On a 6.0L no, not for a miss IF relative compression shows no loss on ALL CYLINDERS. Low power and high crankcase pressure, yes. Bring me a 6.4L with a misfire that is not fuel or wiring related, ABSOLUTELY!!! A 6.4L will mask problems as I am sure many of us have seen. I wouldn't' dream of disassembling a 6.4L or replacing an injector in one without testing the troubled hole at the very least. Sorry buddy, I have been fooled by this engine. If it happens again I am selling my tools and filling out an application at McDonald's. I know better.